A NIH/NHLBI T32-supported post doctoral research position is available in the laboratory of Joshua I. Goldhaber, M.D. Director of Basic Research Programs, in the Heart Institute at Cedars-Sinai Medical Center in Los Angeles, CA. Our lab studies the role of intracellular calcium cycling in cardiac pace making and excitation-contraction coupling in health and disease, with a particular focus on the sodium-calcium exchanger and voltage-sensitive calcium channels. The lab employs a variety of techniques including patch clamp electrophysiology, high resolution voltage and calcium mapping, fluorescence photometry, laser scanning confocal, TIRF, super resolution and multiphoton microscopy, mouse MRI, cardiac cell isolation, and various molecular techniques. The vibrant research program in the Smidt Heart Institute at Cedars-Sinai, in addition to our existing relationships with UCLA, provides excellent opportunities for career development in cardiac research and mentoring for post doctoral researchers.
Typical lab duties may include isolation of cardiomyocytes (ventricular, atrial, or sinoatrial node cells) or whole sinus node and atrial tissue sheets from either mice, rats or rabbits, patch clamping technique to study various ion currents, extensive use of a state of the art laser scanning confocal microscope to study subcellular Ca and other ion characteristics in live myocytes, immunostaining in fixed tissue, qPCR, western blotting, analysis and interpretation of data, preparing manuscripts and posters, presenting slide presentations at national meetings, and applying for fellowships and grants.
Appointments will be for a minimum of two years, with the possibility of an extension based on productivity and research.
At this time, we can only accept applicants who are U.S. citizens or permanent residents (NIH, 2015). PhD candidates must also be within three years of having received their degree, and MD candidates must be within one year of completing their clinical training.
Since its beginning in 1902, Cedars-Sinai has evolved to meet the healthcare needs of one of the most diverse regions in the nation, continually setting new standards in quality and innovation in patient care, research, teaching and community service. Today, Cedars-Sinai is widely known for its national leadership in transforming healthcare for the benefit of patients.Cedars-Sinai is one of the largest nonprofit academic medical centers in the U.S. with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Clinical programs range from primary care for preventing, diagnosing and treating common conditions to specialized treatments for rare, complex and advanced illnesses. In addition, Cedars-Sinai serves the community through its Medical Network, which includes the highly rated Cedars-Sinai Medical Group and Cedars-Sinai Health Associates. Cedars-Sinai has consistently been named one of America’s Best Hospitals by U.S. News & World Report, has received the National Research Corporation’s Consumer Choice Award 18 years in a row for providing the highest quality medical care in Los Angeles, and has the longest running Magnet desig...nation for nursing excellence in California. Cedars-Sinai is a leader in the clinical care and research of heart disease, cancer and brain disorders, among other areas. Pioneering research achievements include using cardiac stem cells to repair damaged hearts, developing minimally invasive surgical techniques and discovering new types of drugs to target cancer more precisely. Cedars-Sinai also impacts the future of healthcare through education programs that encompass everything from highly competitive medical residency and fellowship programs to a biomedical science and translational medicine PhD program, advanced training for nurses and educational opportunities for allied health professionals. Most notably, Cedars-Sinai demonstrates a longstanding commitment to strengthening the Los Angeles community through wide-ranging programs that improve the health of its most vulnerable residents.