We are seeking a highly motivated individual to investigate the genetic basis of complex behaviors, with emphasis on anxiety, learning & memory, extinction of learned associations and addiction. The successful candidate will be perform behavioral pharmacological and viral perturbations of genes involved in these behaviors in the context of genetically-engineered mouse models.
We seek to understand behavioral optimization and the genetic/molecular factors limiting such adaptation. We study the role of the cholinergic system and nicotinic receptors in these processes, focusing on lynx moduators of nicotinic receptor function. We utilize a wide array of techniques: behavioral analyses (fear conditioning, fear extinction, chronic social defeat stress paradigms as examples), circuit replacement, calcium imaging, and synaptic physiological studies in brain slices to characterize underlying mechanisms. We have considerable expertise using a wide range of approaches both in vitro and in vivo: Whole animal studies include behavioral pharmacology, stereotaxic delivery of RNAi, cDNA, and generation of genetic mouse models. In vitro studies including calcium imaging and patch-clamp measurements in acute brain slices, protein purification and co-immunoprecipitation studies.
Ideal candidates will have a Ph.D. and a strong research background in more than one domain of neuroscience, and some experience working with genetic mice. Experience in stereotaxic survival surgery and viral delivery of genes, optogenetics, calcium imaging, intravenous injection, protein purification, and/or nicotinic receptor biology is a plus.
This position is funded by an NIH R01 grant, and the lab has supplemental NSF funding. Lehigh University is one hour north of Philadelphia and 70 miles west of New York City in one of the fastest growing regions in the state.
Ph.D. in Neuroscience or related field.
Internal Number: Ly2018
About Lehigh University
NEUROSCIENCE LAB MANAGER, POSTDOCTORAL or RESEARCH position is available in the laboratory of Julie M. Miwa at Lehigh University. This is a highly multidisciplinary neuroscience laboratory studying plasticity, learning and memory, and addiction with particular emphasis on nicotinic receptors and lynx protein modulators. The laboratory generates mouse models and uses a combination of electrophysiological, molecular, microscopic and behavioral analyses (fear conditioning, extinction, light-dark box, novel object recognition, nicotine force-choice, etc.), to characterize them. For more information see: http://www.lehigh.edu/~inbios/faculty/miwa.html
We seek a highly motivated researcher with a background in neuroscience using mouse genetic models. Essential qualities are good communication skills, internal motivation towards research, and the ability to work cooperatively in a team environment. Position responsibilities include behavioral experimentation, intravenous tail-vein injections in mice, oversight of the genetic lines within the mouse colony, molecular biology, and supervision of students. Experience with viral delivery of antisense/nucleic acids and stereotaxic survival s...urgery or genetic engineering is a plus.
Employer information: Lehigh University provides an ambitious dynamic research environment, and offers excellent research training opportunities. Lehigh University is an EOE. Lehigh University is a small private, R1 university located in eastern Pennsylvania, 60 miles north of Philadelphia and 70 miles west of New York City.
Requirements: Required qualifications are a M.A. or Ph.D. in Neuroscience or a related field and demonstrated research experience. Please send: 1) CV, 2) Cover letter with description of research experience/interests, and 3) Contact information of 3 references to: firstname.lastname@example.org
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