A postdoctoral position is available in the laboratory of Jonathan M. Beckel, Ph.D. in the Department of Pharmacology and Chemical Biology. Our NIH funded project (funded until June 2023) aims to elucidate the mechanisms controlling vesicular and non-vesicular ATP release from the urinary bladder epithelium (urothelium) with a particular focus on how these pathways communicate with the sensory pathways controlling micturition. Studies will involve using a combination of pharmacological agents and genetic techniques both in vivo and in vitro to verify potential targets for the treatment of pathological bladder disorders such as overactive bladder (OAB) and bladder pain syndrome/interstitial cystitis (BPS/IC).
The University of Pittsburgh School of Medicine is ranked #3 in NIH funding, and is internationally recognized as a leader in innovative biomedical research. The city of Pittsburgh is consistently ranked among the most livable cities in the United States. The successful candidate will receive a salary comparable to NIH NRSA levels as well as a generous benefits package. Excellent opportunities exist for publications, presentations at national and international meetings, grant writing, teaching and career advancement. The University of Pittsburgh is an equal opportunity employer.
A Ph.D. or MD/Ph.D. with training in molecular biology, biochemistry, neuroscience, physiology or pharmacology. Previous experience handling animals (rodents), cell culture of cell lines and/or primary cells and molecular biology (cloning, plasmid propagation and viral production) is preferred. Candidate must be willing to work closely with and help train a number of undergraduate and graduate students working in the lab.
Interested candidates should email an updated CV, a brief list of research interests and career goals, and names and contact information for two references to firstname.lastname@example.org.
About Beckel Laboratory - University of Pittsburgh School of Medicine
The laboratory of Jonathan Beckel, Ph.D. resides in the Department of Pharmacology and Chemical Biology at the University of Pittsburgh School of Medicine. Dr. Beckel’s research focuses on the control of the urinary bladder; specifically how the bladder epithelium (also called the urothelium) participates in the sensory limb of the micturition reflex. The ultimate goal of this research is to understand how the urothelium and bladder afferent nerves communicate with each other to transmit sensory information about the bladder to the central nervous system and how changes in this communication play a role in the increased urgency and/or pain often felt by patients suffering from conditions such as overactive bladder (OAB) or Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Recent research has focused on the role of purinergic signaling mechanisms in bladder pathology and the release of ATP from urothelial cells through 1) pannexin channels or 2) vesicular release from secretory lysosomes.
The Department of Pharmacology and Chemical Biology (www.pharmacology.us) consists of 60 primary faculty members, 31 secondary faculty, 24 postdoctoral associates and 19 graduate stu...dents. The Department is currently ranked 9th in NIH funding of Pharmacology departments and has been ranked within the top 10 for over a decade. PCB faculty focus on a wide variety of research topics including receptor pharmacology, cancer pharmacology, neuropharmacology, systems pharmacology, DNA repair, signal transduction, hormone signaling and cardiovascular and renal pharmacology.